靶标 MSH6 别名 DNA mismatch repair protein Msh6; G/T mismatch binding protein; G/T mismatch-binding protein; GTBP; GTMBP; hMSH6; HNPCC 5; HNPCC5; HSAP; MSH 6; MSH6; MSH6_HUMAN; mutS (E. coli) homolog 6; MutS alpha 160 kDa subunit; MutS homolog 6 (E. coli); mutS homolog 6; MutS-alpha 160 kDa subunit; p160; Sperm associated protein 宿主 Rabbit 预测交叉反应 Chicken 稀释比例 WB 1:1000-3000. IHC 1:50-200. Gene ID 2956 保存 Store at -20℃. Avoid freeze / thaw cycles. Swiss Prot P52701 蛋白分子量 120/121/138/153kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Nucleus Cytoplasm 免疫原 A synthetic peptide of Human MSH6 亚型 IgG 纯化方法 Affinity purification 背景资料 This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. Public Immunogen Range 795-845/1360aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse 应用 WB IHC 规格 50ul 100ul