实际分子量 47kDa 靶标 MAEA 别名 1110030D19Rik; Cell proliferation inducing gene 5 protein; Cell proliferation-inducing gene 5 protein; EMLP; EMP; Erythroblast macrophage protein; GID complex subunit 9 FYV10 homolog; GID9; HLC 10; HLC-10; HLC10; Human lung cancer oncogene 10 protein; Lung cancer related protein 10; Macrophage erythroblast attacher; MAEA; MAEA_HUMAN; MGC93683; PIG5; Proliferation inducing gene 5 宿主 Rabbit 预测交叉反应 Bovine;Chicken;Orangutan 稀释比例 WB 1:2000-5000. IHC 1:50-200. Gene ID 10296 保存 Store at -20℃. Avoid freeze / thaw cycles. Swiss Prot Q7L5Y9 蛋白分子量 27/36/40/41/45kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus 免疫原 Recombinant protein of human MAEA 亚型 IgG 纯化方法 Affinity purification 背景资料 Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972).MAEA is required for normal cell proliferation (PubMed:29911972).The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972).Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity).Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581).Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity).May contribute to nuclear architecture and cells division events (Probable). Public Immunogen Range 1-350aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse;Rat 应用 WB IHC 规格 50ul 100ul