实际分子量 63kDa 靶标 GRHL3 别名 Drosophila; Grainyhead like 3; Grainyhead like protein 3 homolog; Grainyhead-like protein 3 homolog; grhl3; GRHL3_HUMAN; Sister of mammalian grainyhead; Sister of mammalian grainyhead protein; SOM; TFCP2L4; Transcription factor CP2 like 4; Transcription factor CP2-like 4 宿主 Rabbit 稀释比例 WB 1:1000-3000. Gene ID 57822 保存 Store at -20℃. Avoid freeze / thaw cycles. Swiss Prot Q8TE85 蛋白分子量 57/62/68/70kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Nucleus 免疫原 Recombinant protein of human GRHL3 亚型 IgG 纯化方法 Affinity purification 背景资料 Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity).Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468).xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity).Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity).Also required for proper development of the oral periderm (PubMed:24360809).No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122). Public Immunogen Range 1-350aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。