实际分子量 24kDa 靶标 NOTCH2NL 别名 FLJ35032;FLJ55807;N2NNotch homolog 2 (Drosophila) N-terminal like;notch 2 N-terminal like;Notch homolog 2 Nterminal like protein;notch homolog 2 N-terminal-like protein 宿主 Rabbit 稀释比例 WB 1:2000-5000. IHC 1:25-100. Gene ID 388677 保存 Store at -20℃. Avoid freeze / thaw cycles. Swiss Prot Q7Z3S9 蛋白分子量 25/26/27kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human NOTCH2NL 亚型 IgG 纯化方法 Affinity purification 背景资料 Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway.Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes,thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production.Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect.Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2.Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation. Public Immunogen Range 1-237aa 克隆类型 Polyclonal Antibody 交叉反应 Human 应用 WB;IHC 规格 50ul 100ul