靶标 HLA-F 别名 CDA12;HLA-5.4;HLA-CDA12;HLAF 宿主 Rabbit 稀释比例 WB 1:1000-3000. Gene ID 3134 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P30511 蛋白分子量 29/39/50kDa 储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Cell membrane 免疫原 Recombinant protein of human HLA-F 亚型 IgG 纯化方法 Affinity purification 背景资料 Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation. Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC). In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides. Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance. Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors. Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production. Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions. May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses. May play a role in inflammatory responses in the peripheral nervous system. Through interaction with KIR3DL2, may protect motor neurons from astrocyte-induced toxicity. Public Immunogen Range 1-350aa 克隆类型 Polyclonal Antibody 交叉反应 Human 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。