靶标 DAB2 别名 DOC2; DOC-2 宿主 Rabbit 稀释比例 WB 1:500-2000. IHC 1:50-200 Gene ID 1601 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P98082 蛋白分子量 82 kDa 储存液 pH7.4 PBS, 0.05% NaN3, 40% Glycerol 亚细胞定位 Cytoplasm Nucleus 免疫原 Fusion protein of human DAB2 亚型 IgG 纯化方法 Antigen affinity purification 背景资料 This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. 克隆类型 Polyclonal Antibody 交叉反应 Human Rat Mouse 应用 WB ELISA IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。