Solarbio K110075P Anti-UBE2O Polyclonal Antibody
- 销售价:
- ¥768.00
- 市场价:
-
¥960.00 - 编号:
- 202303101035750
- 货号:
- K110075P-50ul
-
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商品介绍
英文名称
Anti-UBE2O Polyclonal Antibody
别名
KIAA1734;E2/E3 hybrid ubiquitin-protein ligase UBE2O;Ubiquitin carrier protein O;Ubiquitin-conjugating enzyme E2 O;Ubiquitin-conjugating enzyme E2 of 230 kDa;Ubiquitin-conjugating enzyme E2-230K;Ubiquitin-protein ligase O;(E3-independent) E2 ubiquitin-conjugating enzyme ;
宿主
Rabbit
稀释比例
WB 1:1000-3000.
Gene ID
63893
保存
Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot
Q9C0C9
蛋白分子量
141kDa
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位
Cytoplasm? Nucleus
免疫原
Recombinant protein of human UBE2O
亚型
IgG
纯化方法
Octanoic acid-ammonium sulfate precipitation
背景资料
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).
Public Immunogen Range
1-350aa
克隆类型
Polyclonal Antibody
交叉反应
Human Rat Mouse
应用
WB
规格
50ul 100ul
使用前请离心。如有问题请及时联系我们。
商品参数
商品介绍 | |
---|---|
单位 | 支 |
品牌 | Solarbio |
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