英文名称 Anti-MFN2 Polyclonal Antibody 靶标 AKTIP 别名 CMT2A;CMT2A2;CMT2A2A;CMT2A2B;CPRP1;HMSN6A;HSG;MARF;MFN2;Mitofusin 2 宿主 Rabbit 稀释比例 IHC 1:100-300. Gene ID 9927 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot O95140 蛋白分子量 50/86kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human MFN2 亚型 IgG 纯化方法 Affinity purification 背景资料 Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions. Public Immunogen Range 1-350aa 克隆类型 Polyclonal Antibody 交叉反应 Human Rat Mouse 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。