英文名称 Anti-PHAX Polyclonal Antibody 靶标 AKR7A3 别名 FLJ13193;RNUXA; 宿主 Rabbit 稀释比例 WB 1:1000-3000. IHC 1:50-200. Gene ID 51808 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q9H814 蛋白分子量 44kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Nucleus Cytoplasm 免疫原 A synthetic peptide of PHAX 亚型 IgG 纯化方法 Affinity purification 背景资料 A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA. Public Immunogen Range 140-190/394aa 克隆类型 Polyclonal Antibody 交叉反应 Human 应用 WB IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。