英文名称 Anti-CDKN2A/p16INK4a Rabbit Polyclonal Antibody 别名 CDKN2A;ARF;CDK4I;CDKN2;CMM2;INK4;INK4A;MLM;MTS-1;MTS1;P14;P14ARF;P16;P16-INK4A;P16INK4;P16INK4A;P19;P19ARF;TP16 宿主 Rabbit 稀释比例 WB 1:500-2000.IHC 1:100-400. Gene ID 1029 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P42771/Q8N726 蛋白分子量 8/11/12/13/16/17kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus 免疫原 Recombinant protein of human CDKN2A / p16INK4a. 亚型 IgG 纯化方法 Affinity purification 背景资料 This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. 克隆类型 Polyclonal Antibody 交叉反应 Human 应用 WB IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。