英文名称 Anti-PTPN1 Polyclonal Antibody 别名 PTPN1;PTP1B 宿主 Rabbit 稀释比例 WB 1:1000-3000. Gene ID 5770 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P18031 蛋白分子量 50kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 A synthetic peptide of human PTPN1 亚型 IgG 纯化方法 Affinity purification 背景资料 The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. Public Immunogen Range 335-385/435aa 克隆类型 Polyclonal Antibody 交叉反应 Human 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。