英文名称 Anti-BTBD12 Polyclonal Antibody 靶标 HAUS6 别名 BTBD12, KIAA1784, KIAA1987 宿主 Rabbit 稀释比例 WB 1:1000-3000. Gene ID 84464 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q8IY92 蛋白分子量 166/200kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Nucleus 免疫原 Recombinant protein of human BTBD12 亚型 IgG 纯化方法 Affinity purification 背景资料 Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. Public Immunogen Range 1-350aa 克隆类型 Polyclonal Antibody 交叉反应 Human Rat Mouse 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。