靶标 LILRA2 别名 CD85H; ILT1; LIR-7; LIR7; leukocyte immunoglobulin like receptor A2 宿主 Rabbit 稀释比例 WB 1:1000-3000. Gene ID 11027 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q8N149 蛋白分子量 47/48/51/53kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cell membrane Secreted 免疫原 A synthetic peptide of human LILRA2 亚型 IgG 纯化方法 Octanoic acid-ammonium sulfate precipitation 背景资料 Part of the innate immune responses against microbial infection. Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans. Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling. Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1. Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils. In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4. In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4. Does not bind class I MHC antigens. Public Immunogen Range 60-110/483 克隆类型 Polyclonal Antibody 交叉反应 Human 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。