英文名称 Anti-VPS26B Polyclonal Antibody 别名 Pep8b;VPS26 宿主 Rabbit 稀释比例 IHC 1:100-300. Gene ID 112936 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q4G0F5 蛋白分子量 39kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of Human VPS26B 亚型 IgG 纯化方法 Affinity purification 背景资料 Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1. Public Immunogen Range 1-336aa 克隆类型 Polyclonal Antibody 交叉反应 Human Rat Mouse 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。