英文名称 Anti-RFX3 Polyclonal Antibody 靶标 RFX3 别名 Regulatory factor X 3;Transcription factor RFX3; 宿主 Rabbit 稀释比例 WB 1:2000-5000. IHC 1:50-200. Gene ID 5991 Swiss Prot P48380 保存 Store at -20°C. Avoid freeze / thaw cycles. 蛋白分子量 46/79/84kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Nucleus 免疫原 A synthetic peptide of human RFX3 亚型 IgG 纯化方法 Affinity purification 背景资料 Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12411430). Public Immunogen Range 245-295/749 克隆类型 Polyclonal Antibody 交叉反应 Human Mouse 应用 WB IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。