靶标 IL33 别名 C9orf26;DVS27;IL1F11;NF-HEV;NFEHEV 宿主 Rabbit 稀释比例 IHC 1:50-200. Gene ID 90865 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot O95760 蛋白分子量 26/31kDa 储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. 亚细胞定位 Nucleus Cytoplasm 免疫原 Recombinant protein of human IL33 亚型 IgG 纯化方法 Affinity purification 背景资料 Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury.In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation. Public Immunogen Range 1-270aa 克隆类型 Polyclonal Antibody 交叉反应 Human 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。