英文名称 Anti-PELI1 Polyclonal Antibody 靶标 PELI1 别名 PELI1 宿主 Rabbit 稀释比例 IHC 1:50-200. Gene ID 57162 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q96FA3 蛋白分子量 46kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Nucleus Cytoplasm 免疫原 Recombinant protein of human PELI1 亚型 IgG 纯化方法 Octanoic acid-ammonium sulfate precipitation 背景资料 E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). Public Immunogen Range 1-350aa 克隆类型 Polyclonal Antibody 交叉反应 Human Mouse 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。