英文名称 Anti-DCLRE1C Polyclonal Antibody 靶标 DCLRE1C 别名 DCLRE1C;A-SCID;DCLREC1C;RS-SCID;SCIDA;SNM1C 宿主 Rabbit 稀释比例 WB 1:1000-3000. Gene ID 64421 Swiss Prot Q96SD1 保存 Store at -20°C. Avoid freeze / thaw cycles. 蛋白分子量 50/65/78kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Nucleus 免疫原 A synthetic peptide of human DCLRE1C 亚型 IgG 纯化方法 Affinity purification 背景资料 Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ. Public Immunogen Range 225-275/692 克隆类型 Polyclonal Antibody 交叉反应 Human Rat Mouse 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。