英文名称 Anti-SS18L1 Polyclonal Antibody 靶标 SS18L1 别名 SS18-like protein 1;SYT homolog 1;CREST; KIAA0693; 宿主 Rabbit 稀释比例 IHC 1:50-200. Gene ID 26039 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot O75177 蛋白分子量 29/34/41/43kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Nucleus Cytoplasm 免疫原 Recombinant protein of human SS18L1 亚型 IgG 纯化方法 Affinity purification 背景资料 Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). Public Immunogen Range 1-350aa 克隆类型 Polyclonal Antibody 交叉反应 Human Predicted:Bovine Rat Mouse 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。