英文名称 Anti-BAX Polyclonal Antibody 靶标 BAX 别名 BCL2L4;Bcl2-L-4;Bcl-2-like protein 4;Apoptosis regulator BAX; 宿主 Rabbit 稀释比例 WB 1:1000-3000. Gene ID 581 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q07812 蛋白分子量 5/13/16/18/19/20/21/24kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Cell membrane 免疫原 Recombinant protein of human BAX 亚型 IgG 纯化方法 Affinity purification 背景资料 Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. Public Immunogen Range 1-192aa 克隆类型 Polyclonal Antibody 交叉反应 Human Predicted:Bovine Rat Mouse 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。