英文名称 Anti-HERC2 Polyclonal Antibody 靶标 HERC2 宿主 Rabbit 稀释比例 IHC 1:50-200. Gene ID 8924 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot O95714 蛋白分子量 527KDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus 免疫原 Recombinant protein of human HERC2 亚型 IgG 纯化方法 Affinity purification 背景资料 E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Public Immunogen Range 77-427aa 克隆类型 Polyclonal Antibody 交叉反应 Human Predicted:Fruit fly Mouse 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。