英文名称 Anti-RIT1 Polyclonal Antibody 靶标 RIT1 别名 GTP binding protein Roc1; GTP-binding protein Rit1; Ras like protein expressed in many tissues; Ras like without CAAX 1; Ras-like protein expressed in many tissues; Ras-like without CAAX protein 1; RIBB; Ric like expressed in many tissues; RIT; RIT1; RIT1_HUMAN; ROC1. 宿主 Rabbit 稀释比例 WB 1:500-2000. ELISA 1:5000-10000. IHC-P 1:100-500. IHC-F 1:100-500. IF 1:50-200. Gene ID 6016 保存 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Swiss Prot Q92963 蛋白分子量 25kDa 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 亚细胞定位 Cell membrane 免疫原 KLH conjugated synthetic peptide derived from human RIT1 亚型 IgG 纯化方法 Affinity purification 背景资料 Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.Neuronal activity dramatically increases the concentration of cytosolic Ca2+, which then serves as a second messenger to direct diverse cellular responses. Calmodulin is a primary mediator of Ca2+ signals in the nervous system. Ric, a protein related to the Ras subfamily of small GTPases, has the ability to bind calmodulin. In addition, two Ras-like human proteins, Rin and Rit (Ric-related gene expressed in many tissues), which are 71% and 66% identical to RIC respectively, share related G2 domains with Ric. While most members of the Ras subfamily are plasma membrane-associated and generally require a C-terminal isoprenyl group to bind to the plasma membrane, Rit and Rin lack the recognition signal for C-terminal prenylation. Transiently expressed Rit and Rin are plasma membrane-localized because both proteins contain a C-terminal cluster of basic amino acids, which provides a mechanism for membrane association. Rin binds calmodulin through a C-terminal binding motif. Rit and Ric are widely expressed, whereas expression of Rin is restricted to the neuron system. In conclusion, Rit and Rin define a novel subfamily of Ras-related proteins. Public Immunogen Range 141-219/219 克隆类型 Polyclonal Antibody 交叉反应 Predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。