英文名称 Anti-PTK2B Polyclonal Antibody 靶标 PTK2B 别名 PTK2B;CADTK;CAKB;FADK2;FAK2;PKB;PTK;PYK2;RAFTK;Pyk2 宿主 Rabbit 稀释比例 IHC 1:50-200. Gene ID 2185 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q14289 蛋白分子量 111/116kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus 免疫原 Recombinant protein of human PTK2B 亚型 IgG 纯化方法 Affinity purification 背景资料 This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. Public Immunogen Range 660-1010aa 克隆类型 Polyclonal Antibody 交叉反应 Human Rat Mouse 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。