靶标 STAT5B 别名 STAT 5; STAT 5A; STAT5; STAT5A; Signal transducer and activator of transcription 5B; STA5B_HUMAN; STAT5; Stat5b 宿主 Rabbit 预测交叉反应 Cow;Pig 稀释比例 IHC 1:50-200. Gene ID 6777 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P51692 蛋白分子量 90kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus 免疫原 A synthetic peptide of human STAT5B 亚型 IgG 纯化方法 Affinity purification 背景资料 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008] Public Immunogen Range 737-787/787aa 克隆类型 Polyclonal Antibody 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。