靶标 ACO1 别名 IREB1;IREBP;IRP1 宿主 Rabbit 预测交叉反应 Cow;Rabbit;Chimpanzee;Chicken 稀释比例 WB 1:1000-3000.;IHC 1:100-300. Gene ID 48 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P21399 蛋白分子量 98kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 A synthetic peptide of human ACO1 亚型 IgG 纯化方法 Octanoic acid-ammonium sulfate precipitation 背景资料 The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants Public Immunogen Range 130-180/889aa 克隆类型 Polyclonal Antibody 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。