靶标 IL4R 别名 IL4R;CD124;IL-4RA;IL4RA 宿主 Rabbit 稀释比例 IHC 1:100-300. Gene ID 3566 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P24394 蛋白分子量 26/88/90kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cell membrane Secreted 免疫原 A synthetic peptide of human IL4R 亚型 IgG 纯化方法 Octanoic acid-ammonium sulfate precipitation 背景资料 This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. Public Immunogen Range 410-460/825aa 克隆类型 Polyclonal Antibody 交叉反应 Human 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。