英文名称 Anti-DLG4 Polyclonal Antibody 靶标 DLG4 别名 PSD95;SAP-90;SAP90 宿主 Rabbit 稀释比例 WB 1:1000-3000. Gene ID 1742 Swiss Prot P78352 保存 Store at -20°C. Avoid freeze / thaw cycles. 蛋白分子量 80/85kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cell membrane Cytoplasm 免疫原 A synthetic peptide of human DLG4 亚型 IgG 纯化方法 Affinity purification 背景资料 Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. Public Immunogen Range 550-600/724 克隆类型 Polyclonal Antibody 交叉反应 Human Rat Mouse 应用 WB 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。