英文名称 Anti-PD-1/CD279 Polyclonal Antibody 靶标 PD-1/CD279 别名 CD279, hPD 1, hPD l, PD 1, PD1, PD-1, PDCD1, programmed cell death 1, Protein PD 1, SLEB2 宿主 Rabbit 稀释比例 WB 1:300-1000. IHC 1:400-1600.IF 1:50-500. Gene ID 5133 保存 Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. Swiss Prot Q15116 蛋白分子量 32kDa 储存液 PBS with 0.02% sodium azide and 50% glycerol pH 7.3. 亚细胞定位 Cell membrane 免疫原 Fusion protein of human PD-1/CD279 亚型 IgG 纯化方法 Affinity purification 背景资料 Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436). It has been reported that PD-1 is heavily glycosylated and migrates with an apparent molecular mass of 47-55 kDa on SDS-PAGE , which is larger than its predicted mass of 32 kDa (PMID: 8671665; 17640856; 17003438). 克隆类型 Polyclonal Antibody 交叉反应 Human Mouse 应用 WB ELISA IF IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。