靶标 ULK3 别名 DKFZP434C131; FLJ90566; Serine/threonine-protein kinase ULK3; ULK3_HUMAN; unc 51 like kinase 3 (C. elegans); Unc-51-like kinase 3. 宿主 Rabbit 稀释比例 WB 1:1000-3000. IHC 1:50-200. Gene ID 25989 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q6PHR2 蛋白分子量 24/53/54kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human ULK3 亚型 IgG 纯化方法 Affinity purification 背景资料 Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. Public Immunogen Range 1-215aa 克隆类型 Polyclonal Antibody 交叉反应 Human Predicted:Chicken Rat Mouse 应用 WB IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。