靶标 PAK5 别名 Serine/threonine-protein kinase PAK 5;p21-activated kinase 5;PAK-5;p21-activated kinase 7;PAK-7;KIAA1264;PAK7; 宿主 Rabbit 稀释比例 IHC 1:100-300. Gene ID 57144 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q9P286 蛋白分子量 81kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus 免疫原 Recombinant protein of human PAK5 亚型 IgG 纯化方法 Affinity purification 背景资料 Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. Public Immunogen Range 1-350aa 克隆类型 Polyclonal Antibody 交叉反应 Human Rat Mouse 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。