英文名称 Anti-NOTCH2(Cleaved-Ala1734) Polyclonal Antibody 靶标 NOTCH2(Cleaved-Ala1734) 别名 AGS2;HJCYS;hN2;notch 2 宿主 Rabbit 稀释比例 IHC 1:50-200. Gene ID 4853 Swiss Prot Q04721 保存 Store at -20°C. Avoid freeze / thaw cycles. 蛋白分子量 265kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus 免疫原 A synthetic peptide of human NOTCH2(Cleaved-Ala1734) 亚型 IgG 纯化方法 Affinity purification 背景资料 Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). Public Immunogen Range 1695-1745/2471 克隆类型 Polyclonal Antibody 交叉反应 Human Rat Mouse 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。