靶标 STAT5A/B 别名 MGF; STAT5 宿主 Rabbit 稀释比例 IHC 1:100-300. Gene ID 6776/6777 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P42229/P51692 蛋白分子量 87/90/91kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus 免疫原 A synthetic peptide of human STAT5A/B 亚型 IgG 纯化方法 Affinity purification 背景资料 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] Public Immunogen Range 55-105/787aa 克隆类型 Polyclonal Antibody 交叉反应 Human Predicted:Cow Pig Sheep Rat Mouse 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。