靶标 ATP2A2 别名 ATP2B;DAR;DD;SERCA2;ATP2A2/SERCA2;ATP2A2 宿主 Rabbit 稀释比例 WB 1:1000-3000. IHC 1:50-200. Gene ID 488 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P16615 蛋白分子量 110/112/115kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human ATP2A2 亚型 IgG 纯化方法 Affinity purification 背景资料 This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (PubMed:16402920). Acts as a regulator of TNFSF11-mediated Ca2+ signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity). Public Immunogen Range 483-700aa 克隆类型 Polyclonal Antibody 交叉反应 Human Rat Mouse 应用 WB IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。