Solarbio K110827P Anti-PLK2 Polyclonal Antibody
- 销售价:
- ¥768.00
- 市场价:
-
¥960.00 - 编号:
- 202302241035090
- 货号:
- K110827P-50ul
-
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商品介绍
英文名称
Anti-PLK2 Polyclonal Antibody
靶标
PLK2
别名
PLK-2;hPlk2;hSNK;SNK;
宿主
Rabbit
稀释比例
WB 1:1000-3000.
Gene ID
10769
Swiss Prot
Q9NYY3
保存
Store at -20°C. Avoid freeze / thaw cycles.
蛋白分子量
78kDa
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位
Cytoplasm
免疫原
A synthetic peptide of human PLK2
亚型
IgG
纯化方法
Affinity purification
背景资料
Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.
Public Immunogen Range
305-355/685
克隆类型
Polyclonal Antibody
交叉反应
Human Rat Mouse
应用
WB
规格
50ul 100ul
使用前请离心。如有问题请及时联系我们。
商品参数
商品介绍 | |
---|---|
单位 | 支 |
品牌 | Solarbio |
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