靶标 JMY 别名 FLJ37870;WHAMM2 宿主 Rabbit 稀释比例 WB 1:1000-3000. IHC 1:100-300. Gene ID 133746 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q8N9B5 蛋白分子量 110/111kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus 免疫原 A synthetic peptide of human JMY 亚型 IgG 纯化方法 Affinity purification 背景资料 Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). Public Immunogen Range 805-855/988aa 克隆类型 Polyclonal Antibody 交叉反应 Human 应用 WB IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。