靶标 MDM2 别名 MDM2;ACTFS;HDMX;hdm2 宿主 Rabbit 稀释比例 WB 1:500-2000. IF 1:50-200. Gene ID 4193 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q00987 蛋白分子量 11-14/24-55kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus nucleolus nucleoplasm 免疫原 Recombinant protein of human MDM2. 亚型 IgG 纯化方法 Affinity purification 背景资料 This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. 克隆类型 Polyclonal Antibody 交叉反应 Human Rat Mouse 应用 WB IF 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。