Solarbio K110816P Anti-GNAI3 Polyclonal Antibody
- 销售价:
- ¥768.00
- 市场价:
-
¥960.00 - 编号:
- 202302241034978
- 货号:
- K110816P-50ul
-
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商品介绍
英文名称
Anti-GNAI3 Polyclonal Antibody
靶标
GNAI3
别名
G(i) alpha-3;87U6;ARCND1;
宿主
Rabbit
稀释比例
WB 1:1000-3000.
Gene ID
2773
Swiss Prot
P08754
保存
Store at -20°C. Avoid freeze / thaw cycles.
蛋白分子量
41kDa
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位
Cytoplasm
免疫原
A synthetic peptide of human GNAI3
亚型
IgG
纯化方法
Affinity purification
背景资料
Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K+ channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935).
Public Immunogen Range
304-354/354
克隆类型
Polyclonal Antibody
交叉反应
Human Rat Mouse
应用
WB
规格
50ul 100ul
使用前请离心。如有问题请及时联系我们。
商品参数
商品介绍 | |
---|---|
单位 | 支 |
品牌 | Solarbio |
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