靶标 RAD17 别名 RAD17;CCYC;HRAD17;R24L;RAD17SP;RAD24 宿主 Rabbit 稀释比例 IHC 1:100-300. Gene ID 5884 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot O75943 蛋白分子量 57/66/75/77kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Nucleus 免疫原 A synthetic peptide of human RAD17 亚型 IgG 纯化方法 Affinity purification 背景资料 The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. Public Immunogen Range 1-51/681aa 克隆类型 Polyclonal Antibody 交叉反应 Human Predicted:Chimpanzee Mouse 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。