英文名称 Anti-IPO4 Polyclonal Antibody 靶标 IPO4 别名 Importin-4;Imp4;Importin-4b;Imp4b;RanBP4;IMP4B;RANBP4; 宿主 Rabbit 稀释比例 WB 1:1000-3000. IHC 1:50-200. Gene ID 79711 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q8TEX9 蛋白分子量 119kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus 免疫原 Recombinant protein of human IPO4 亚型 IgG 纯化方法 Affinity purification 背景资料 Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Public Immunogen Range 1-350aa 克隆类型 Polyclonal Antibody 交叉反应 Human Mouse 应用 WB IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。