靶标 HLA-C 别名 HLA-C;D6S204;HLA-JY3;HLAC;HLC-C;MHC;PSORS1 宿主 Rabbit 稀释比例 WB 1:1000-3000. IHC 1:100-300. Gene ID 3107 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P10321 蛋白分子量 37/41kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cell membrane Cytoplasm 免疫原 A synthetic peptide of human HLA-C 亚型 IgG 纯化方法 Affinity purification 背景资料 HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described Public Immunogen Range 40-90/366aa 克隆类型 Polyclonal Antibody 交叉反应 Human Predicted:Dog Chimpanzee Monkey 应用 WB IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。