英文名称 Anti-TNIP1 Polyclonal Antibody 靶标 TNIP1 别名 ABIN-1;Naf1;Nip40-1;VAN;hVAN;KIAA0113;NAF1; 宿主 Rabbit 稀释比例 WB 1:1000-3000. IHC 1:100-300. Gene ID 10318 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q15025 蛋白分子量 62/63/64/65/66/72kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Nucleus 免疫原 Recombinant protein of human TNIP1 亚型 IgG 纯化方法 Octanoic acid-ammonium sulfate precipitation 背景资料 Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. Public Immunogen Range 1-350aa 克隆类型 Polyclonal Antibody 交叉反应 Human Mouse 应用 WB IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。