靶标 ARHGAP17 别名 MST066; MST110; MSTP038; MSTP066; MSTP110; NADRIN; Neuron associated developmentally regulated protein; PP367; PP4534 宿主 Rabbit 稀释比例 IHC 1:50-200. Gene ID 55114 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q68EM7 蛋白分子量 26/43/64/88/91/94/95kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 A synthetic peptide of human ARHGAP17 亚型 IgG 纯化方法 Affinity purification 背景资料 Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca2+-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. Public Immunogen Range 470-520/881aa 克隆类型 Polyclonal Antibody 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。