靶标 RFWD3 别名 RNF201 宿主 Rabbit 稀释比例 IHC 1:50-200. Gene ID 55159 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q6PCD5 蛋白分子量 85kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Nucleus Cytoplasm 免疫原 A synthetic peptide of human RFWD3 亚型 IgG 纯化方法 Affinity purification 背景资料 E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination. Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Public Immunogen Range 60-110/774aa 克隆类型 Polyclonal Antibody 交叉反应 Human 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。