靶标 CDC27 别名 ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E; H-NUC; HNUC; NUC2 宿主 Rabbit 稀释比例 WB 1:500-2000. IHC 1:100-300. Gene ID 996 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P30260 蛋白分子量 92/93kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Nucleus Cytoplasm 免疫原 A synthetic peptide of human CDC27 亚型 IgG 纯化方法 Affinity purification 背景资料 The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014] Public Immunogen Range 280-330/824aa 克隆类型 Polyclonal Antibody 交叉反应 Human Rat 应用 WB IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。