英文名称 Anti-HLA-B（HLA Class I） Polyclonal Antibody 靶标 HLA-B 别名 HLA-B;AS;B-4901;HLAB;Bw-47;Bw-50;SPDA1;HLA Class I 宿主 Rabbit 稀释比例 WB 1:1000-2000.IHC 1:50-200.IF 1:50-200 Gene ID 3106 保存 Store at -20℃. Avoid freeze / thaw cycles. Swiss Prot P01889 蛋白分子量 40kDa 储存液 Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. 亚细胞定位 Membrane Single-pass type I membrane protein 免疫原 A synthetic peptide of human HLA-B 亚型 IgG 纯化方法 Affinity purification 背景资料 HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. 克隆类型 Polyclonal Antibody 交叉反应 Human Rat Mouse 应用 WB IF IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。