英文名称 Anti-CHMP4A Polyclonal Antibody 靶标 CHMP4A 别名 CHMP4a;SNF7-1;hSnf-1;Vps32-1;hVps32-1;C14orf123;SHAX2;CDA04;HSPC134; 宿主 Rabbit 稀释比例 IHC 1:50-200. Gene ID 29082 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q9BY43 蛋白分子量 25/30kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human CHMP4A 亚型 IgG 纯化方法 Affinity purification 背景资料 Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Public Immunogen Range 1-222aa 克隆类型 Polyclonal Antibody 交叉反应 Human Predicted:Bovine 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。