英文名称 Anti-ENPP2 Polyclonal Antibody 靶标 ENPP2 别名 E-NPP 2;Autotaxin;LysoPLD;ATX;PDNP2; 宿主 Rabbit 稀释比例 WB 1:1000-3000;IHC 1:50-200. Gene ID 5168 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q13822 蛋白分子量 99/102/105kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Secreted 免疫原 A synthetic peptide of human ENPP2 亚型 IgG 纯化方法 Affinity purification 背景资料 Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:15769751, PubMed:26371182, PubMed:27754931, PubMed:14500380, PubMed:12354767,). Major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:27754931, PubMed:14500380). Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility (PubMed:14500380). Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:15769751, PubMed:12176993). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation (PubMed:11559573). Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein (PubMed:1733949). May have a role in induction of parturition (PubMed:12176993). Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor (PubMed:1733949, PubMed:11559573). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (PubMed:21393252). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:21393252). Public Immunogen Range 560-610/863aa 克隆类型 Polyclonal Antibody 交叉反应 Human;Mouse;Rat 应用 WB;IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。