英文名称 Anti-ADAM17(Cleaved-Arg215) Polyclonal Antibody 靶标 ADAM17(Cleaved-Arg215) 别名 ADAM 17;CD156b;CSVP;TACE;TNF-alpha convertase;TNF-alpha-converting enzyme;Snake venom-like protease; 宿主 Rabbit 稀释比例 IHC 1:100-300. Gene ID 6868 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot P78536 蛋白分子量 79/93kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm Cell membrane 免疫原 A synthetic peptide of human ADAM17(Cleaved-Arg215) 亚型 IgG 纯化方法 Affinity purification 背景资料 Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). Public Immunogen Range 200-250/824aa 克隆类型 Polyclonal Antibody 交叉反应 Human 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。