靶标 FBXO6 别名 FBG2;FBS2;FBX6;Fbx6b 宿主 Rabbit 预测交叉反应 Bovine 稀释比例 IHC 1:50-200. Gene ID 26270 保存 Store at -20°C. Avoid freeze / thaw cycles. Swiss Prot Q9NRD1 蛋白分子量 33kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human FBXO6 亚型 IgG 纯化方法 Affinity purification 背景资料 Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication. Public Immunogen Range 1-294aa 克隆类型 Polyclonal Antibody 交叉反应 Human Mouse Rat Predicted:Bovine 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。