英文名称 Anti-PMEPA1 Polyclonal Antibody 靶标 PMEPA1 别名 Protein TMEPAI;STAG1;TMEPAI 宿主 Rabbit 稀释比例 IHC 1:50-200. Gene ID 56937 Swiss Prot Q969W9 保存 Store at -20°C. Avoid freeze / thaw cycles. 蛋白分子量 26/28/32kDa 储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. 亚细胞定位 Cytoplasm 免疫原 Recombinant protein of human PMEPA1 亚型 IgG 纯化方法 Affinity purification 背景资料 Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). Public Immunogen Range 1-238aa 克隆类型 Polyclonal Antibody 应用 IHC 规格 50ul 100ul 使用前请离心。如有问题请及时联系我们。